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KMID : 0370219970410040530
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Yakhak Hoeji
1997 Volume.41 No. 4 p.530 ~ p.532
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Substrate Specificity of the Macrolide-Phosphotransferase K
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김숙경/Kim SK
오태권/백문창/김병각/최응칠/Oh TG/Baek MC/Kim BK/Choi EC
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Abstract
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The MICs of various macrolide, lincosamide and streptogramin B antibiotics against highly erythromycin-resistant Escherichia coli 209K strain were evaluated. E. coli 209K showed high MICs against 14-membered macrolides and the relatively weaker resistance to 16-membered macrolides, lincosamides and streptogramin B. The macrolide-phosphotransferase K from E. coli 209K showed greater substrate specificity to the 14-membered macrolide antibiotics than to the 16-membered macrolide antibiotics, lincosamide and streptogramin B. Therefore, it was considered that the high resistance was due to the macrolide-phosphotransferase K.
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